Garlic Extracts Up-regulate IL-4 and IL-13 Cytokines and Increase the Goblet Cell Numbers in Eimeria vermiformis Infected Mice

Cytokines (IL-17, IL-23, and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago.

Systemic lupus erythematosus (SLE) is the most common autoimmune disease. It is characterized by the presence of hundreds of autoantibodies against many organs and tissues, including the presence of a large number of autoantibodies, which are specific to self-antigens mainly of nuclear origin such as Smith antigen, double-stranded DNA (dsDNA), anti-Sjögren’s syndrome-related antigen A and B (SS...

Function in Mice Deficient in IL-4 and IL-13 IgE Generation and Mast Cell Effector

Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity.

In this investigation, we have examined the integrated relationship between IL-13, IL-4, and IL-5 for the development of airways hyperreactivity (AHR) in a model of asthma in BALB/c mice. Sensitization and aeroallergen challenge of both wild-type (WT) and IL-13 gene-targeted (IL-13-/-) mice induced allergic disease that was characterized by pulmonary eosinophilia and AHR to beta-methacholine. A...

Anti-inflammatory cytokines (IL-4, IL-10, IL-13) in plasma during mesenteric infarction.

We have recently reported that excessive synthesis of proinflammatory cytokines such as interleukin-6 (IL6) and IL-8 may play a role in the pathogenesis of mesenteric infarction. IL-4, IL-10 and IL-13 are classified as anti-inflammatory cytokines because they reduce the secretion of proinflammatory cytokines by stimulated monocytes/macrophage. During several inflammatory states anti-inflammator...

IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages.

The cysteinyl (Cys) leukotrienes (LT)C(4), LTD(4), and LTE(4), are lipid mediators that have been implicated in the pathogenesis of asthma. The human LTD(4) receptor (CysLT(1)R) was recently cloned and characterized. The present work was undertaken to study the potential modulation of CysLT(1)R expression by the Th2 cytokines IL-13 and IL-4. In this study, we report that IL-13 up-regulates CysL...